Keywords

• Lexacalcitol in China
• Lexacalcitol good supplier
• High quality Lexacalcitol

Quick Details

• ProName: High quality Lexacalcitol good supplie...
• CasNo: 131875-08-6
• Molecular Formula: C29H48O4
• Appearance: white powders
• Application: Intermediates
• DeliveryTime: According to your demand
• PackAge: 1g, 10g, 100g, 200g, 1kg, 5kg
• Port: any port in China
• ProductionCapacity: Metric Ton/Day
• Purity: 98%
• Storage: ealed, keep in the ventilated, dry
• Transportation: as requested
• LimitNum: 0 Metric Ton

Superiority

Factory Supply 131875-08-6 with Efficient Delivery, Factory Sells Lexacalcitol

Lexacalcitol (KH1060), a vitamin D analog, is potent regulators of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases

KH1060 metabolism could be blocked by the cytochrome P450 inhibitor, ketoconazole. KH1060 was not an effective competitor of C24 oxidation of 1alpha,25-(OH)2D3. Certain hydroxylated metabolites of KH1060 retained significant biological activity in vitamin D-dependent reporter gene systems (chloramphenicol acetyltransferase). KH 1060 inhibited PBMC proliferation and decreased TNF-alpha levels in IBD patients and this effect was synergistic with anti-TNF-alpha. VDR protein levels were significantly increased by PBMC treatment with KH 1060 or anti-TNF-alpha or their combination in ulcerative colitis (UC) patients, and decreased in Crohn's disease (CD) patients, treating the cells with KH 1060. A synergistic inhibition was registered combining KH 1060 and anti-TNF, at well-defined concentrations. 0.1 nM KH 1060 produced a significant decrease in TNF-alpha levels, determined by ELISA, although less remarkable than in the presence of anti-TNF.

Chemvon Biotechnology Co. Ltd is a high-technology pharmaceutical and fine chemical company, which is speciallized in RD, manufacturing and sales of APIs (Active Pharmaceutical Ingredients) and some organic intermediates. With the experience and specialization in technology of asymmetric synthesis, total synthesis of natural products, organometallic reactions, chromatographic chiral separation, we supply high quality products of APIs, intermediates, speciality chemicals. and our contract services including research manufacture and custom synthesis from laboratory to commercial production are also offered on a confidential basis. Chemvon puts great emphasis on product quality and service as followed in details: Custom chemical services: 1. Contract custom manufacturing of intermediates and API's from microgrms up to multi tonnes scale; 2. Contract process research and upscaling studies; 3. Contract research in structure-activity of drug moleculars Products: 1. Vitamins and steroids; 2. Organic intermediates, heterocyclic compounds including monomers of polymer materials and some building blocks; 3. Chiral synthons with multi-step reactions. Welcome to you and your visit, let us make progress hand in hand!

Details

Synonym: Lexacalcitol; KH1060; KH-1060; KH 1060;

IUPAC/Chemical Name: (5Z,7E,20R)-20-((4-Ethyl-4-hydroxyhexyl)oxy)-9,10-secopregna-5,7,10(19)-triene-1alpha,3beta-diol

InChi Key: KLZOTDOJMRMLDX-GXOIKENLSA-N

InChi Code: InChI=1S/C29H48O4/c1-6-29(32,7-2)16-9-17-33-21(4)25-13-14-26-22(10-8-15-28(25,26)5)11-12-23-18-24(30)19-27(31)20(23)3/h11-12,21,24-27,30-32H,3,6-10,13-19H2,1-2,4-5H3/b22-11+,23-12-/t21-,24+,25-,26+,27-,28-/m1/s1

SMILES Code: C[C@@H](OCCCC(O)(CC)CC)[C@H]([C@]1(CCC/2)C)CC[C@@]1([H])C2=C\C=C3C[C@H](O)C[C@@H](O)C\3=C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00