Keywords

• High quality of Inecalcitol
• Inecalcitol Good Supplier
• Inecalcitol In China

Quick Details

• ProName: High quality of Inecalcitol Good Suppl...
• CasNo: 163217-09-2
• Molecular Formula: C26H40O3
• Appearance: white powder
• Application: a vitamin D receptor agonist
• DeliveryTime: ship immediately after confirmation
• PackAge: According to your demand
• Port: shanghai
• ProductionCapacity: Metric Ton/Day
• Purity: 99%
• Storage: store in dry and cool place.
• Transportation: by air or by sea
• LimitNum: 1 Gram

Superiority

High quality of Inecalcitol Good Supplier In China

Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist with a K_d of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities. IC50 & Target: Kd: 0.53 nM (vitamin D receptor (VDR)) In Vitro: Inecalcitol (0.1-10 nM; 48 hours) treatment of LNCaP cells results in decreased expression of both protein and mRNA of Pim-1 in a dose-dependent manner. Inecalcitol (0.1-10 nM; 48 hours) also decreases ETV1 expression levels in a dose-dependent manner.
Inecalcitol (10-14 days) inhibits the growth of LNCaP and HL-60 cells with ED₅₀ values of 4.0 nM and 0.28 nM, respectively. In Vivo: Inecalcitol (1.3 mg/kg; i.p.; 3 times per week; for 42 days) inhibits androgen-responsive prostate cancer growth in vivo
Pharmacokinetic studies show that plasma half-life of Inecalcitol (C57Bl/6J mice; 1.3 mg/kg; i.p.) is 18.3 minutes in mice.

Details

Name

Inecalcitol

Synonyms

Molecular Structure

Molecular Formula

C26H40O3

Molecular Weight

400.59

CAS Number (Or Watson Number for Non-CAS Products)

163217-09-2

EINECS

Specs/Standards

97%,99%