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CAS NO.571170-77-9
high quality Laropiprant direct manufacturer in China
Laropiprant, aslo known as MK-0524, was a drug used in combination with niacin to reduce blood cholesterol (LDL and VLDL) that is no longer sold, due to increases in side-effects with no cardiovascular benefit. Laropiprant itself has no cholesterol lowering effect, but it reduces facial flushes induced by niacin. Laropiprant acts as a selective DP1 antagonist, reducing the vasodilation.
Laropiprant(Cardaptive; MK 0524) is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 μM for the DP1 and DP2 receptors, respectively. Laropiprant(Cardaptive; MK 0524) inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively. In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion. At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a murine model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia.
product name : Laropiprant
cas no.:571170-77-9
| Catalog Num | A11483 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 571170-77-9 |
| Formula | C21H19ClFNO4S |
| M. Wt | 435.9 |
| Purity | >98% |
| Synonyms | Cardaptive, MK 0524, MK-0524 |
| SMILES | CS(=O)(=O)C1=C2C(=CC(=C1)F)C3=C(N2CC4=CC=C(C=C4)Cl)[@](CC3)CC(=O)O |
| Storage |
Store lyophilized at -20ºC, keep desiccated. |