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CAS NO.59122-46-2
High quality Misoprostol on hot selling manufacturer
Misoprostol, a synthetic E prostaglandin, has been shown to prevent tissue corrosion induced by certain anti-inflammatory compounds. This E1 analog displays agonist activity at EP receptors and decreases NSAID-induced gastric ulcerations. Additionally, Misoprostol has been shown to have negative effects on the murine nervous system by altering the intracellular calcium levels in neuroblastoma cells. Other experiments have noted that Misoprostol has the ability to affect serum concentration of β2-microglobulin, which is related to antigen presentation on hepatocyte surface. Misoprostol is an activator of EP1, EP2, EP3 and EP4
Misoprostol is a cytoprotective prostaglandin E1 analog that displays agonist activity at EP receptors. Ki values are 120, 250, 67 and 67 nM at cloned mouse EP1, EP2, EP3 and EP4 receptors respectively. Prevents NSAID-induced gastric ulceration.
Misoprostol is an analog of prostaglandin E1 (PGE1; Item No. 13010) and an agonist of the PGE2 receptor subtypes EP2 and EP3. It binds to EP1, EP2, EP3-III, and EP4 receptors (Kis = 35.675, 10.249, 0.319, 5.499 μM, respectively) and is selective for EP receptors over DP, FP, IP, and TP receptors (Kis = >100 μM for all). Misoprostol inhibits electrically induced twitch contraction in isolated guinea pig ileum circular muscle and vas deferens (EC50s = 102.92 and 4.3 nM, respectively), which endogenously express high levels of EP2 and EP3 receptors, respectively.It inhibits FMLP-induced superoxide anion generation in human neutrophils (EC50 = 0.35 μM). Misoprostol inhibits ethanol-induced gastric lesion formation in rats (ED50 = 0.31 μg/kg). Formulations containing misoprostol have been used in the prevention of NSAID-induced gastric ulcers.
Misoprostol is a synthetic prostaglandin E1 analog that is commonly used for medical abortion, management of miscarriage, cervical priming, management of postpartum hemorrhage, and induction of labor. Because of misoprostol’s wide use in reproductive health, the drug is in the World Health Organization (WHO) Model List of Essential Medicines.
Catalogue Number | M368750 |
Chemical Name | Misoprostol, 1% in cellulose |
Synonyms | (11α,13E)-(+/-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic Acid Methyl Ester; Cytotec; Misogon; Misoprostil; SC 29333; |
CAS Number | 59122-46-2 |
Molecular Formula | C??H??O? |
Appearance | White Solid |
Melting Point | >200ºC (dec.) |
Molecular Weight | 382.53 |
Storage | -20°C Freezer |
Solubility | DMSO (Slightly), Water (Slightly, Heated, Sonicated) |
Category | Standards; Pharmaceutical/API Drug Impurities/Metabolites; Lipids/Fatty Acids, Glycerol Derivatives; |
Applications | Misoprostol |