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CAS NO.661-19-8
top quality n-Docosanol factory in China
Docosanol is an aliphatic alcohol that has broad-spectrum antiviral activity against viruses with a lipid envelope (ID50s = 3-12 nM for inhibition of replication). It inhibits herpes simplex virus type 1 (HSV-1) replication and protein synthesis in Vero cells. It also inhibits HSV-2 plaque formation and virus production in wild-type Vero cells and cells resistant to acyclovir (Item No. 14160). Docosanol acts by prohibiting the HSV envelope from fusing with the plasma membrane. Formulations containing docosanol have been used in the topical treatment of HSV-1.
1-Docosanol, a 22-carbon-long saturated alcohol, exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Some studies have demonstrated that docosanol inhibits fusion between the plasma membrane and the HSV envelope, thus preventing viral entry into target cells and subsequent viral replication.
1-Docosanol works as a surfactant in cosmetics. 1-Docosanol cream has also been approved by the US Food and Drug Administration as a safe and effective topical treatment for herpes labialis
Catalogue Number | D678855 |
Chemical Name | 1-Docosanol |
Synonyms | 1-Docosonol; Abreva; Behenic Alcohol; Behenyl 80 Alcohol; Behenyl Alc. 80; Behenyl Alcohol; Conol 2265; Conol 2280; Docosanol; Docosyl Alcohol; Hainol 22S; IK 2; IK 2 (alcohol); Kalcohl 220; Kalcohl 22080; Kalcol 22080; Lanette 22; NAA 422; NSC 8407; Nacol 22-97; Nacol 22-98; Nacol C 22; Stenol 1822; Stenol 1822A; Tadenan; Toho BH 65; n-Docosanol |
CAS Number | 661-19-8 |
Molecular Formula | C??H??O |
Appearance | White to Off-White Solid |
Melting Point | 70-73°C |
Molecular Weight | 326.6 |
Storage | Refrigerator |
Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
Category | Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites; |