Keywords

• Delamanid
• high purity Delamanid
• Delamanid manufacturer

Quick Details

• ProName: Delamanid
• CasNo: 681492-22-8
• Appearance: sold
• Application: Pharmaceutical use
• DeliveryTime: Stocks
• PackAge: according to customers' requirements
• Port: any port in China
• ProductionCapacity: Metric Ton/Day
• Purity: 98
• LimitNum: 0 Metric Ton

Superiority

Chinese Factory Supply 681492-22-8 Delamanid with Competitive Price

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry.

From origins as a research group in technology service, chemvon has progressed into an integrated company with a kilo lab and a pilot plant offering a range of APIs, NCEs and some organic intermediates.

Quality: Adopting the leading technology to assure the high quality.

Price: Offering the best price among the suppliers in China.

Rich material and energe make us control the cost effective

Afrer-sale service: Chemvon will take charge of everthing if there is any question after the sale.

Certificates: We can offer ISO9001 certificates that you need for importing.

Delamanid is used for the treatment of multi-drug-resistant tuberculosis. It functions by blocking the synthesis of mycolic acids in Mycobacterium tuberculosis, the organism which causes tuberculosis, thus destabilising its cell wall.

Delamanid is an antimycobacterial compound. It is active against clinical isolates of M. tuberculosis that are susceptible (MIC90s = 0.01194-0.01248 μg/ml) or resistant to rifampicin (Item No. 14423), isoniazid (Item No. 20378), ethambutol (Item No. 23713), and/or streptomycin (Item No. 21211; MIC90s = 0.01221-0.01341 μg/ml). It inhibits the synthesis of methoxy- and keto-mycolic acid in the M. bovis strain BCG (IC50s = 0.036 and 0.021 μg/ml, respectively). Delamanid (0.1, 0.3, and 1 μg/ml) inhibits the growth of the M. tuberculosis strain H37Rv in infected THP-1 cells. It decreases lung bacterial burden in a mouse model of M. tuberculosis infection in a dose-dependent manner.

Delamanid is a new antituberculosis drug that inhibits mycolic acid synthesis and has shown potent in vitro and in vivo activity against drug-resistant strains of Mycobacterium tuberculosis.

Details

Buy Reliable Quality 681492-22-8 Delamanid

Chemvon Biotechnology ( Shanghai ) Co. Ltd., established at the end of the 2004.

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry.

From origins as a research group in technology service, chemvon has progressed into an integrated company with a kilo lab and a pilot plant offering a range of APIs, NCEs and some organic intermediates. 

Formal Name

(2R)-2,3-dihydro-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl]phenoxy]methyl]-imidazo[2,1-b]oxazole

CAS Number

681492-22-8

Synonyms

OPC-67683
Molecular Formula

C25H25F3N4O6

Formula Weight

534.5

Purity

≥98%

Formulation

A crystalline solid

Solubility(Learn about Variance in Solubility)

DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: partially soluble
λmax

220, 244, 316 nm

SMILES

FC(F)(F)OC(C=C1)=CC=C1OC2CCN(C3=CC=C(OC[C@]4(C)OC5=NC([N+]([O-])=O)=CN5C4)C=C3)CC2

InChi Code

InChI=1S/C25H25F3N4O6/c1-24(15-31-14-22(32(33)34)29-23(31)38-24)16-35-18-4-2-17(3-5-18)30-12-10-20(11-13-30)36-19-6-8-21(9-7-19)37-25(26,27)28/h2-9,14,20H,10-13,15-16H2,1H3/t24-/m1/s1

InChi Key

XDAOLTSRNUSPPH-XMMPIXPASA-N

Shipping & Storage Information
Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 2 years