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CAS NO.112965-21-6
Supply Calcipotriol in stock manufacturer
Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor. IC50 & Target: Vitamin D receptor In Vitro: When NHEK cells are not stimulated with IL-17A or IL-22, Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8, confirming our previous study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20 and 40 nM in a dose dependent manner[1]. Treatment of natural killer (NK) cells with drugs modulates their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH)2D3, Calcipotriol or FTY720 for 4 h. All three concentrations of 1,25(OH)2D3, Calcipotriol and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation. In Vivo: One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived. Survival is equally distributed between the groups. The weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002) compare with placebo (linear regression model).
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Product Name |
Calcipotriol |
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CAS No. |
112965-21-6 |
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Molecular Formula |
C27H40O3 |
Molecular Weight |
412.61 |
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Batch No. |
140101 |
Mfg. Date |
Jan.10,2014 |
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Quantity |
15G |
Retest. Date |
Jan.9,2016 |
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Items |
Specifications |
Results |
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Appearance |
White or almost white crystalline powder |
Conforms |
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Identification |
a) IR |
IR chromatograph Conforms to the characteristic peak of R.S. |
Conforms |
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b) HPLC |
The retention time of the major peak in the chromatogram Conforms to the characteristic peak of R.S. |
Conforms |
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Related substances |
Known impurity |
Impurity C((5E)-calcipotriol) |
NMT1.0% |
0.60% |
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Impurity D (24-epi-calcipotriol) |
NMT1.0% |
0.40% |
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Impurity I (suprasterol of calcipotriol) |
NMT0.10% |
ND |
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Any other impurity |
NMT 0.1% |
0.09% |
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Total impurities |
NMT2.5% |
1.3% |
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Heavy metals |
<20ppm |
Conforms |
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LOD |
Not more than 1.0% |
0.4% |
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Solvent residue |
Acetone≤0.5% |
0.1% |
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Assay |
95.5~102.0% |
98.9% |
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White Crystalline Solid
Leo Denmark (Denmark)
An antipsoriatic. A vitamin D3 analogue with low calcemic activity
antipsoriatic;viamin D receptor (VDR) affinity
A labelled antipsoriatic. A vitamin D3 analogue with low calcemic activity.