Keywords

• high quality Daclatasvir
• Daclatasvir factory
• Daclatasvir in China

Quick Details

• ProName: High quality Daclatasvir factory in Ch...
• CasNo: 1214735-16-6
• DeliveryTime: ship immediately after confirmation.
• PackAge: as your request
• Port: China main port
• ProductionCapacity: Metric Ton/Day
• Purity: 98%
• Storage: store in dry and cool place.
• Transportation: by air or by sea
• LimitNum: 1 Gram

Superiority

High quality Daclatasvir factory in China

BMS-790052 is a first-in-class, highly selective inhibitor of hepatitis C virus (HCV) NS5A with an EC₅₀ of 9–50 pM. BMS-790052 is one of the most potent inhibitors of HCV replication reported so far. The mean EC₅₀ values of BMS-790052 are 50 and 9pM for HCV genotype 1a and 1b replicons, respectively. BMS-790052 displays a therapeutic index (CC₅₀/EC₅₀) of at least 105 and is inactive towards a panel of 10 RNA and DNA viruses, with EC₅₀ higher than 10μM. This confirms BMS-790052's specificity for HCV. In Huh7 cells harboring the HCV genotype 1b replicons, BMS-790052 blocks both transient and stable HCV genome replication, with EC₅₀ values raging from 1–15 pM. BMS-790052 (100 pM or 1 nM) has been shown to alter the subcellular localization and biochemical fractionation of NS5A. BMS-790052 inhibits hybrid replicons containing HCV genotype-4 NS5A genes with EC₅₀ of 7–13 pM. Residue 30 of NS5A is an important site for BMS-790052-mediated resistance in the hybrid replicons.

Details

Name

Daclatasvir

Synonyms

Molecular Structure

Molecular Formula

C40H50N8O6

Molecular Weight

738.88

CAS Number (Or Watson Number for Non-CAS Products)

1214735-16-6

EINECS

Appearance

Specs/Standards

98%min

Use

Daclatasvir Intermediate.