High quality Daclatasvir factory in China CAS NO.1214735-16-6

Min.Order: 1 Gram
Payment Terms: L/C,T/T

Product Details

Keywords

high quality Daclatasvir
Daclatasvir factory
Daclatasvir in China

Quick Details

ProName: High quality Daclatasvir factory in Ch...
CasNo: 1214735-16-6
DeliveryTime: ship immediately after confirmation.
PackAge: as your request
Port: China main port
ProductionCapacity: Metric Ton/Day
Purity: 98%
Storage: store in dry and cool place.
Transportation: by air or by sea
LimitNum: 1 Gram

Superiority

High quality Daclatasvir factory in China

BMS-790052 is a first-in-class, highly selective inhibitor of hepatitis C virus (HCV) NS5A with an EC₅₀ of 9–50 pM. BMS-790052 is one of the most potent inhibitors of HCV replication reported so far. The mean EC₅₀ values of BMS-790052 are 50 and 9pM for HCV genotype 1a and 1b replicons, respectively. BMS-790052 displays a therapeutic index (CC₅₀/EC₅₀) of at least 105 and is inactive towards a panel of 10 RNA and DNA viruses, with EC₅₀ higher than 10μM. This confirms BMS-790052's specificity for HCV. In Huh7 cells harboring the HCV genotype 1b replicons, BMS-790052 blocks both transient and stable HCV genome replication, with EC₅₀ values raging from 1–15 pM. BMS-790052 (100 pM or 1 nM) has been shown to alter the subcellular localization and biochemical fractionation of NS5A. BMS-790052 inhibits hybrid replicons containing HCV genotype-4 NS5A genes with EC₅₀ of 7–13 pM. Residue 30 of NS5A is an important site for BMS-790052-mediated resistance in the hybrid replicons.

Catalog Num	A10159
Actions	Inhibitor
CAS No.	1214735-16-6, 1009119-64-5
Formula	C40H50N8O6
M. Wt	738.9
Purity	>98%
Synonyms	Daclatasvir
SMILES	CC(C)[@@H](C(=O)N1CCC[@]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[@@H]6CCCN6C(=O)[@](C(C)C)NC(=O)OC)NC(=O)OC
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.