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CAS NO.147245-92-9
buy High quality GlatiraMer acetate in China
Glatiramer (acetate) is a mixture of synthetic polypeptides composed of four amino acids found in myelin basic protein (MBP): L-Alanine, L-glutamic acid, L-lysine, and L-tyrosine. It prevents MBP from binding to MHC class II molecules in the periphery and induces the production of immunomodulatory molecules considered to be anti-inflammatory. It also increases proliferation of oligodendrocyte and neuronal precursor cells in the central nervous system of mice. Formulations containing glatiramer (acetate) are used to treat patients with multiple sclerosis, particularly the relapsing-remitting type
Glatiramer acetate, a synthetic analogue of myelin basic protein and an immunomodulating agent, can be used for the research of multiple sclerosis. Glatiramer acetate exhibits strong and promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression.
Glatiramer acetate is a random basic synthetic copolymer of L-alanine, L-lysine, l-glutamic acid and L-tyrosine in a molar ratio of 6:1.9:4.7:1. Glatiramer acetate is an immunomodulator used in treatment of multiple sclerosis.
Catalogue Number | G406802 |
Chemical Name | Glatiramer Acetate-Dx |
Synonyms | L-Alanine polymer with L-Glutamic Acid L-Lysine L-Tyrosine Acetate-Dx ; L-Tyrosine polymer with L-Alanine L-Glutamic Acid L-Lysine Acetate-Dx; 511: PN: WO2010103292 PAGE: 64 claimed sequence-Dx; Cop 1-Dx; Copaxone-Dx; Copolymer 1-Dx; L-Glutamic Acid peptide with L-Alanine L-Lysine L-Tyrosine Acetate Salt-Dx; Protiramer-Dx; TV 5010-Dx; |
CAS Number | 147245-92-9 |
Alternate CAS # | 147245-92-9 unlabelled |
Molecular Formula | xC?D?H?NO? xC? H??N?O? xC?H?NO? xC?H?NO? xC?D?HO? |
Category | Standards; Phenethylamines/Amphetamines; |
Applications | Glatiramer Acetate-Dx is labelled Glatiramer Acetate (G406800) which is a random basic synthetic copolymer of L-alanine, L-lysine, l-glutamic acid and L-tyrosine. Glatiramer acetate is an immunomodulator used in treatment of multiple sclerosis. |