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CAS NO.159351-69-6
Supply Everolimus in Stock fast delivery
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that, as part of two distinct complexes (mTORC1 and mTORC2), plays pivotal roles in intracellular signaling. Everolimus is a hydroxyethyl ether rapamycin (Item No. 13346) derivative that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM. It is orally available and shows improved pharmacokinetics and pharmacodynamics over rapamycin. Through its inhibition of mTOR, everolimus inhibits cell proliferation, metabolism, and angiogenesis in certain types of cancer. It also acts as an immunosuppressive agent in the context of organ transplantation
Everolimus is a mTOR inhibitor. Inhibits tumor proliferation in vitro and in vivo. Inhibits VEGF-induced HUVEC proliferation in vitro, but does not affect tumor vascular permeability in mouse models. Immunosuppressant. Activates autophagy.
Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cytokine-mediated lymphocyte proliferation. Everolimus can be used as an immunosuppressant in the treatment of renal cell cancer and other cancers.
| Catalogue Number | E945400 |
| Chemical Name | Everolimus (~90% pure) |
| Synonyms | 40-O-(2-Hydroxyethyl)rapamycin; 42-O-(2-Hydroxy)ethyl Rapamycin; Afinitor; Certican; RAD; RAD 001; SDZ-RAD; XIENCE V; |
| Impurity | Everolimus EP Impurity C |
| CAS Number | 159351-69-6 |
| Molecular Formula | C??H??NO?? |
| Appearance | White to Light Beige Solid |
| Melting Point | 100 - 104ºC |
| Molecular Weight | 958.24 |
| Storage | Hygroscopic, -20°C Freezer, Under Inert atmosphere |
| Solubility | Chloroform (Slightly), Methanol (Slightly, Sonicated) |
| Stability | Hygroscopic |
| Category | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation. |