Chemvon Biotechnology Co. Ltd.
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Business Type:Lab/Research institutions
Tel: 86-21-58550039;86-21-31268550-8004
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Province/state: shanghai
City: shanghai
Street: Suite B-10#, 6999 Chuansha Road, Pudong District, Shanghai 201202, China
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CAS NO.170729-80-3
Aprepitant 170729-80-3 factory in China
Aprepitant is an antiemetic chemical compound that belongs to “substance P” antagonists (SPA) with its effect being blocking the neurokinin 1(Nk1) receptor. It is used for the prevention of acute and delayedchemotherapy-induced nausea and vomiting(CINV) and for prevention ofpostoperative nausea and vomiting. It can also be used for the treatment of cyclic vomiting syndrome and late-stage chemotherapy induced vomiting occurring during cancer treatment. Aprepitant alleviates the case of vomiting in patients through balking the signals released by Nk1 receptors. Nk1 is a G-protein-coupled receptor with its ligand being substance P (SP). The high concentration of SP is required for the vomiting reflex. Aprepitant blocks the process of SP-NK1 signaling in activating the vomiting reflex.
Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry.
From origins as a research group in technology service, chemvon has progressed into an integrated company with a kilo lab and a pilot plant offering a range of APIs, NCEs and some organic intermediates.
Quality: Adopting the leading technology to assure the high quality.
Price: Offering the best price among the suppliers in China.
Rich material and energe make us control the cost effective
Afrer-sale service: Chemvon will take charge of everthing if there is any question after the sale.
Certificates: We can offer ISO9001 certificates that you need for importing.
| Aprepitant | CAS 170729-80-3 | Brand: Hyper |
| MW: 534.43 | MSDS: Avaiable | |
| MF :C23H21F7N4O3 | Sample: Avaiable | |
| Category: API | Min order: 10grams | |
| Quality standard : NLT 99.0% | Place of Origin:China | |
| Application | is an antiemetic chemical compound that belongs to a class of drugs called substance P antagonists (SPA). It mediates its effect by blocking the neurokinin 1 (NK1) receptor. Aprepitant is manufactured by Merck & Co. under the brand name Emend for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting. |
|
| Technical Information | Physical State: Solid Storage: Store at -20° C Melting Point: 244-246°C (lit.) |
|
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 250.0 to 255.0 °C |
| Specific rotation [a]20/D | +67.0 to +71.0 deg(C=1,MeOH) |
Properties (reference)
| Melting Point | 252 °C |
| Specific Rotation | 69° (C=1,MeOH) |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Ethanol |