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CAS NO.170729-80-3
Buy High quality Aprepitant cost
Aprepitant an antiemetic and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3 nM; IC50 = 0.09 nM for the human receptor). It is selective for NK1 over NK3 receptors (Ki = 454.1 nM for human NK3).1 In vivo, aprepitant (1 mg/kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P (Item No. 24035). It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting.
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Catalogue Number | A729800 |
Chemical Name | Aprepitant |
Synonyms | 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend; L 754030; MK 0869; MK 869; ONO 7436; |
CAS Number | 170729-80-3 |
Molecular Formula | C??H??F?N?O? |
Appearance | White to Pale Beige Solid |
Melting Point | 242-250°C |
Molecular Weight | 534.43 |
Storage | -20°C Freezer |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Category | Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; |
Applications | Aprepitant is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3). |