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Quick Details

• ProName: Hot sale Aprepitant with fast delivery...
• CasNo: 170729-80-3
• Molecular Formula: C23H21F7N4O3
• Appearance: Off-White to Light Yellow Cyrstalline ...
• Application: A novel selective neurokinin-1 (NK-1) ...
• DeliveryTime: 3-5 days after conformation
• PackAge: According to your demand
• Port: any port in China
• ProductionCapacity: 200 Kilogram/Week
• Purity: 99
• Storage: store in a tightly closed container, i...
• Transportation: as requested
• LimitNum: 1 Gram

Superiority

Hot sale Aprepitant with fast delivery good supplier

Aprepitant is a neurokinin-1 (NK-1) receptor antagonist and belongs to the treating agents of vomiting during chemotherapy of cancer. It was first successfully developed by Merck Company (German). In March 2003, the US Food and Drug Administration approved it for being used in the treatment of chemotherapy vomiting. This product has a high selective affinity to human beings while has a low affinity to serotonin, dopamine and glucocorticoid receptor affinity. Aprepitant, when combined with 5-HT3 receptor inhibitors (such as ondansetron hydrochloride) and the corticosteroid dexamethasone, can further alleviate the cisplatin-induced acute and (or) delayed emesis. Applying this drug alone can have some preventive effect.
Substance P, a kind of tachykinin (neurokinin), is mainly distributed in the neurons of central and peripheral nervous system. It is related with a lot of features such as vomiting, depression, inflammatory pain and other inflammatory diseases. The role of substance P is mediated by NK-1 receptor which is a kind of G protein receptor coupled with phosphoinositide signaling pathway. The drug has blocking effect on the NK-1 receptor through direct binding to this receptor, thus further obtaining the treatment of substance P-mediated diseases.
Aprepitant can selectively prevent the binding of substance P with NK-1 receptor in the central nervous system to take antiemetic effect. Therefore, it can be used for treating the nausea and vomiting caused by the moderately and highly emetogenic chemotherapy.

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry.

From origins as a research group in technology service, chemvon has progressed into an integrated company with a kilo lab and a pilot plant offering a range of APIs, NCEs and some organic intermediates.

Quality: Adopting the leading technology to assure the high quality.

Price: Offering the best price among the suppliers in China.

Rich material and energe make us control the cost effective

Afrer-sale service: Chemvon will take charge of everthing if there is any question after the sale.

Certificates: We can offer ISO9001 certificates that you need for importing.

Details

 1.Base Date

 Name:Aprepitant(mk 0869)

 CAS No.:170729-80-3

 Molecular formular:C23H21F7N4O3

 Aprepitant Chemical structure:

 2. Details of Aprepitant

 Superlist Name:Aprepitant (mk 0869)

 Molecular Formula:C23H21F7N4O3

 CAS No.:170729-80-3

 Purity:99%

 Synonyms:Aprepitant; 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-  fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one

 Molecular Weight:534.43

 Appearance:white powder