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Chemvon Biotechnology Co. Ltd.

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Chemvon Biotechnology Co. Ltd.

Business Type:Lab/Research institutions

Audited Supplier

Main Products:
Atocalcitol ,Inecalcitol,Alvimopan ,Fosaprepitant, Bimatoprost,Lubiprostone,Tafluprost
Year Established:
2008
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Chemvon Biotechnology Co. Ltd.

Country: China (Mainland)

Business Type:Lab/Research institutions

Mr.peter

Tel: 86-21-58550039;86-21-31268550-8004

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Tel: 86-21-58550039;86-21-31268550-8004

Fax: 86-21-50790419

URL: http://www.chemvon.com

Province/state: shanghai

City: shanghai

Street: Suite B-10#, 6999 Chuansha Road, Pudong District, Shanghai 201202, China

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Supply lowest price lurasidone factory

CAS NO.367514-87-2

  • Min.Order: 1 Gram
  • Payment Terms: L/C,T/T
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Product Details

Keywords

  • Supply lurasidone
  • lowest price lurasidone
  • lurasidone factory

Quick Details

  • ProName: Supply lowest price lurasidone factory
  • CasNo: 367514-87-2
  • Molecular Formula: C28H36N4O2S
  • Appearance: White powder
  • Application: Api
  • DeliveryTime: ship immediately after confirmation.
  • PackAge: as your requirement
  • Port: shanghai
  • ProductionCapacity: Metric Ton/Day
  • Purity: 99%
  • Storage: Store in dry and cool place.
  • Transportation: by air or by sea
  • LimitNum: 1 Gram

Superiority

Supply lowest price lurasidone factory

The atypical antipsychotic lurasidone (also known as SM-13496) was approved in the United States in 2010 as an oral agent for the treatment of patients with schizophrenia. Lurasidone has potent affinity for D2 (Ki= 1.7 nM) and 5-HT2A (Ki= 2.0 nM) receptors and acts as an antagonist at both receptors. It is also a partial agonist at the 5-HT1A receptor and, unlike other atypical agents, is a potent antagonist at the 5-HT7 receptor; both of these activities are thought to confer beneficial cognitive properties. Lurasidone is further differentiated by its lack of affinity for muscarinic and histamine H1 receptors and its weak affinity for the 5-HT2C receptor. Antagonism at H1 and 5-HT2C receptors has been implicated in weight gain associated with atypical agents, while muscarinic receptor antagonism is associated with cognitive deficits.

Lurasidone is developed by Japan's Dainippon Sumitomo Pharma which is an atypical antipsychotic,and is a classification of drug registration 3.1 class, it is suitable for the treatment of patients with schizophrenia. Its efficacy is Determined in four six weeks in adult patients with schizophrenia controlled studies. The exact mechanism of the treatment of schizophrenia, like other atypical antipsychotics ,is not very clear,and may be related to the antagonism of the dopamine D2 and serotonin 2A (5-HT2A) receptors. For the treatment of schizophrenia, a study has reported lurasidone can improve cognitive function.
October 28, 2010 ,the FDA approved lurasidone hydrochloride (lurasidone HCI) tablets once a day for the first-line treatment of patients with schizophrenia, the trade name is Latuda.
Dosage: The recommended starting dose is 40 mg/d, the effective dose range is 40~120 mg /· d, the maximum recommended dose is 80 mg /· d. It should be taken with food.
Adverse reaction: common adverse reactions are somnolence, akathisia, nausea, Parkinson's disease-like symptoms and emotional anxiety. Lurasidone has no physical dependence, less likely to cause weight gain, it does not cause glucose, lipids (lipids), it changs the period between ECG and QT.

Details

Catalogue Number L474958
Chemical Name Lurasidone
Synonyms (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione; 2-[[(1R,2R)-2-[[4-(1,2-Benzoisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-(3aS,4R,7S,7aR)-4,7-methano-1H-isoindole-1,3(2H)-dione
CAS Number 367514-87-2
Molecular Formula C??H??N?O?S
Appearance Off-White Solid
Melting Point 146-149°C
Molecular Weight 492.682
Storage -20°C Freezer
Solubility Chloroform (Slightly), DMSO (Slightly)
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications Lurasidone (cas# 367514-87-2) is a useful research chemical.