Sales promotion qualified Alfacalcidol factory CAS NO.41294-56-8

Sales promotion qualified Alfacalcidol factory

1α-Hydroxyvitamin D3 is a synthetic analog of Calcitiol (the hormonal form of vitamin D3), which shows identical potency with respect to stimulation of intestinal calcium absorption and bone mineral mobilization. It is a vitamin D source.

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity.1-hydroxy Vitamin D₃ is a synthetic prodrug which is converted by cytochrome P450 isoforms to the vitamin D receptor agonist 1,25-dihydroxy vitamin D₃ Such prodrugs are effective in suppressing the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism, an action which requires the vitamin D receptor. 1-hydroxy Vitamin D₃ supports bone growth both in postmenopausal women and in glucocorticoid-induced osteoporosis.It also provides renal and cardiovascular protection during chronic kidney disease

Alfacalcidol is a member of the class of D3 vitamins that is calciol in which the hydrogen at the 1alpha position is replaced by a hydroxy group. It is an active metabolite of cholecalciferol, which performs important functions in regulation of the calcium balance and the bone metabolism. It has a role as a bone density conservation agent. It is a member of D3 vitamins, a seco-cholestane, a hydroxycalciol and a diol. It derives from a calciol.

• Product name

  1alpha-Hydroxyvitamin D3 (Alfacalcidol), Bone resorption inhibitor

• Description

  Bone resorption inhibitor. Metabolite of cholecalciferol.

• Alternative names

  • Alfacalcidol

• Biological description

  Metabolite of cholecalciferol (ab143594). Shows osteoprotective effects in vivo. Orally active.

• Purity

  > 98%

• CAS Number

  41294-56-8

• Chemical structure