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CAS NO.57333-96-7
Top quality Tacalcitol golden supplier in China
Tacalcitol, the second vitamin D analog developed as a topical antipsoriatic, was introduced for keratosis, psoriasis, ichthyosis, pityriasis rubra pilaris and palmoplantar pustulosis and keratoderma. It shows improvement in appearance of skin lesions for psoriasis patients without significant side effects. In patients with psoriasis vulgaris, it effectively inhibits keratinocyte growth. Some in vitro studies have shown that tacalcitol inhibits interleukin-1-α-induced granulocyte macrophage colony-stimulating-factor mRNA expression of the human dermal microvascular endothelial cells, which may be involved in mediation of angioproliferation in skin inflammation.
Tacalcitol is a synthetic vitamin D3 analog. This compound has been shown to regulate calcium levels and induce nerve growth factor production in epidermal keratinocytes. Additionally, Tacalcitol has been noted to promotes normal bone development by regulating calcium. Furthermore, Tacalcitol modulates immunological and inflammatory processes.
Tacalcitol
(1¦Á£¬3¦Â-5Z£¬7E£¬24R)-9£¬10-Secoholesta-5£¬7£¬10(19)-triene-1£¬3£¬24-triol;l¦Á£¬24-Dihydroxycholecalciferol;l¦Á£¬24R-Dihy-droxyvitaminD3;[5Z,7E,24R,(+)]-9,10-Secocholesta-5,7,10(19)-triene-1¦Á,3¦Â,24-triol;1¦Á,24(R)-DihydroxyvitaminD3;1¦Á,24R-DihydroxyvitaminD3;(1a,3b,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol;C12919
C27H44O3
416.63646
57333-96-7
98%
Tacalcitol Intermediate.
| Catalog Num | A15251 |
|---|---|
| CAS No. | 57333-96-7 |
| Formula | C27H44O3 |
| M. Wt | 416.65 |
| Purity | >98% |
| Synonyms | 1,24(R)-Dihydroxyvitamin D3, 1.alpha.,24R-Dihydroxyvitamin D3 |
| SMILES | CC(C)C(CCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C)O |
| Storage |
Store lyophilized at -20ºC, keep desiccated. |