Keywords

• Misoprostol manufacturer
• High quality Misoprostol
• Misoprostol on hot selling

Quick Details

• ProName: High quality Misoprostol on hot sellin...
• CasNo: 59122-46-2
• Molecular Formula: C22H38O5
• Appearance: water-soluble, viscous liquid
• Application: Misoprostol is a synthetic prostagland...
• DeliveryTime: ship immediately after confirmation
• PackAge: According to your demand
• Port: any port in China
• ProductionCapacity: Metric Ton/Day
• Purity: 99
• Storage: 20°C
• Transportation: as requested
• LimitNum: 1 Gram
• Grade: Pharma Grade

Superiority

High quality Misoprostol on hot selling manufacturer

Misoprostol, a synthetic E prostaglandin, has been shown to prevent tissue corrosion induced by certain anti-inflammatory compounds. This E₁ analog displays agonist activity at EP receptors and decreases NSAID-induced gastric ulcerations. Additionally, Misoprostol has been shown to have negative effects on the murine nervous system by altering the intracellular calcium levels in neuroblastoma cells. Other experiments have noted that Misoprostol has the ability to affect serum concentration of β2-microglobulin, which is related to antigen presentation on hepatocyte surface. Misoprostol is an activator of EP₁, EP₂, EP₃ and EP₄

Misoprostol is a cytoprotective prostaglandin E₁ analog that displays agonist activity at EP receptors. K_i values are 120, 250, 67 and 67 nM at cloned mouse EP₁, EP₂, EP₃ and EP₄ receptors respectively. Prevents NSAID-induced gastric ulceration.

Misoprostol is an analog of prostaglandin E₁ (PGE₁; Item No. 13010) and an agonist of the PGE₂ receptor subtypes EP₂ and EP₃. It binds to EP₁, EP₂, EP_3-III, and EP₄ receptors (K_is = 35.675, 10.249, 0.319, 5.499 μM, respectively) and is selective for EP receptors over DP, FP, IP, and TP receptors (K_is = >100 μM for all). Misoprostol inhibits electrically induced twitch contraction in isolated guinea pig ileum circular muscle and vas deferens (EC₅₀s = 102.92 and 4.3 nM, respectively), which endogenously express high levels of EP₂ and EP₃ receptors, respectively.It inhibits FMLP-induced superoxide anion generation in human neutrophils (EC₅₀ = 0.35 μM). Misoprostol inhibits ethanol-induced gastric lesion formation in rats (ED₅₀ = 0.31 μg/kg). Formulations containing misoprostol have been used in the prevention of NSAID-induced gastric ulcers.

Details

Misoprostol is a synthetic prostaglandin E1 analog that is commonly used for medical abortion, management of miscarriage, cervical priming, management of postpartum hemorrhage, and induction of labor. Because of misoprostol’s wide use in reproductive health, the drug is in the World Health Organization (WHO) Model List of Essential Medicines.