High purity DelaManid in China cost CAS NO.681492-22-8

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Keywords

High purity DelaManid
DelaManid cost
DelaManid in China

Quick Details

ProName: High purity DelaManid in China cost
CasNo: 681492-22-8
Application: Pharmaceutical use
DeliveryTime: ship immediately after confirmation
PackAge: According to your demand
Port: any port in China
ProductionCapacity: Metric Ton/Day
Purity: 98
Transportation: as requested
LimitNum: 0 Metric Ton

Superiority

High purity DelaManid in China cost

Delamanid is used for the treatment of multi-drug-resistant tuberculosis. It functions by blocking the synthesis of mycolic acids in Mycobacterium tuberculosis, the organism which causes tuberculosis, thus destabilising its cell wall.

Delamanid is an antimycobacterial compound. It is active against clinical isolates of M. tuberculosis that are susceptible (MIC₉₀s = 0.01194-0.01248 μg/ml) or resistant to rifampicin (Item No. 14423), isoniazid (Item No. 20378), ethambutol (Item No. 23713), and/or streptomycin (Item No. 21211; MIC₉₀s = 0.01221-0.01341 μg/ml). It inhibits the synthesis of methoxy- and keto-mycolic acid in the M. bovis strain BCG (IC₅₀s = 0.036 and 0.021 μg/ml, respectively). Delamanid (0.1, 0.3, and 1 μg/ml) inhibits the growth of the M. tuberculosis strain H37Rv in infected THP-1 cells. It decreases lung bacterial burden in a mouse model of M. tuberculosis infection in a dose-dependent manner.

Delamanid is a new antituberculosis drug that inhibits mycolic acid synthesis and has shown potent in vitro and in vivo activity against drug-resistant strains of Mycobacterium tuberculosis.

Details

Formal Name

(2R)-2,3-dihydro-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl]phenoxy]methyl]-imidazo[2,1-b]oxazole

CAS Number

681492-22-8

Synonyms

OPC-67683

Molecular Formula

C₂₅H₂₅F₃N₄O₆

Formula Weight

534.5

Purity

≥98%

Formulation

A crystalline solid

Solubility(Learn about Variance in Solubility)

DMF: 25 mg/ml
DMSO: 20 mg/ml
Ethanol: partially soluble

λ_max

220, 244, 316 nm

SMILES

FC(F)(F)OC(C=C1)=CC=C1OC2CCN(C3=CC=C(OC[C@]4(C)OC5=NC([N+]([O-])=O)=CN5C4)C=C3)CC2

InChi Code

InChI=1S/C25H25F3N4O6/c1-24(15-31-14-22(32(33)34)29-23(31)38-24)16-35-18-4-2-17(3-5-18)30-12-10-20(11-13-30)36-19-6-8-21(9-7-19)37-25(26,27)28/h2-9,14,20H,10-13,15-16H2,1H3/t24-/m1/s1

InChi Key

XDAOLTSRNUSPPH-XMMPIXPASA-N