Keywords

• Beraprost SodiuM in stock
• Beraprost SodiuM immediately delivery
• Beraprost SodiuM good supplier

Quick Details

• ProName: Beraprost SodiuM in stock / immediatel...
• CasNo: 88475-69-8
• Application: API
• DeliveryTime: ship immediately after confirmation.
• PackAge: as your request
• Port: China main port
• ProductionCapacity: Metric Ton/Day
• Purity: 99%
• Storage: store in dry and cool place.
• Transportation: by air or by sea
• LimitNum: 1 Gram

Superiority

Beraprost SodiuM in stock / immediately delivery /good supplier

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Beraprost is a platelet aggregation inhibitor in healthy subjects and in diabetic subjects at similar doses.

Beraprost sodium treatment increased the expression of hepatic SIRT1 and peroxisome proliferator activated receptor α (PPARα) in human-derived HepG2 cells treated with fructose. These effects were blocked in HepG2 cells after transfection with siRNA against SIRT1. MiR-200a was highly expressed during fructose treatment and was down regulated by beraprost sodium (P<0.05). A luciferase assay showed that miR-200a regulated SIRT1 by binding to the 3' UTR. Overexpression of miR-200a inhibited expression of hepatic SIRT1. These results demonstrated that SIRT1 pathway mediated the effects of beraprost sodium on attenuation of hepatic lipid disorders induced by fructose and revealed the primary role of miR-200a in the regulation of hepatic SIRT1 by beraprost sodium. Reference: Metabolism. 2017 Aug;73:9-21. #(17)30144-0/fulltext

Beraprost sodium, a stable prostacyclin analog, was showed to improve survival rates in two different rat models, anti-glomerular basement membrane (GBM) glomerulonephritis (GN) and 5/6 nephrectomized (Nx) chronic kidney disease (CKD) rats. In the anti-GBM rat, beraprost sodium (0.2 and 0.6 mg/kg/day) improved survival rate (hazard ratio for beraprost sodium 0.6 mg/kg/day group, 0.10; 95% confidence interval, 0.01 to 0.68). Subsequently, in the 5/6 Nx CKD rat, beraprost sodium (0.6 mg/kg/day) improved survival rate (hazard ratio for beraprost sodium, 0.46; 95% confidence interval, 0.23 to 0.92), serum creatinine doubling time and the slope of the reciprocal of serum creatinine. Reference: Eur J Pharmacol. 2013 Aug 15;714(1-3):325-31. #

Details

Name

Beraprost sodium

Synonyms

beraprostsodium;ML 1129;PROCYLIN;TRK 100;BERAPROST SODIUM SALT;2,3,3A-8B-TETRAHYDRO-2-HYDROXY-1-(3-HYDROXY-4-METHYL-1-OCTEN-6-YNYL)-1H-CYCLOPENTA[B]BENZOFURAN-5-BUTANOIC ACID, SODIUM SALT;2,3,3a-8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta[b]benzofuran-5-butanoic acid, sodium salt;1H-Cyclopenta[b]benzofuran-5-butanoic acid, 2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-, monosodium salt

Molecular Structure

Molecular Formula

C24H29NaO5

Molecular Weight

420.47

CAS Number (Or Watson Number for Non-CAS Products)

88475-69-8

EINECS

Appearance

Specs/Standards

Enterprise Standard